PySSA
Python rich client for visual protein Sequence to Structure Analysis is an open software project that aims to combine PyMOL(TM) and ColabFold to enable the prediction and analysis of 3D protein structures for the scientific end-user.
Available for Windows operating systems only.
What is PySSA?
Combines PyMOL and ColabFold to enable the prediction and analysis of 3D protein structures for the scientific end-user.
Allows the creation of managed and shareable projects with defined workflows for the prediction and analysis of protein structures.
PySSA has a more user-friendly interface for interacting with PyMOL, such as creating high-quality ray-tracing images in a few clicks.
Precision Visualization – Accurately assess protein structures with PyMOL’s clear display of reference (green) and predicted (blue) models for reliable structural alignment analysis.
Customizable Display – Enhance your workflow with PySSA’s intuitive panel, allowing quick adjustments to background colors, protein representations, and visualization styles.
Streamlined Research – Optimize structural biology projects with seamless integration between PyMOL and PySSA, enabling efficient data interpretation and presentation.
Interactive Distance Analysis – Explore residue-pair relationships with PySSA’s dynamic distance diagram, where selected pairs are highlighted in red for immediate visual feedback.
Comprehensive Data Integration – Combine distance frequency histograms and alignment tables in one view for efficient cross-validation of structural models.
Streamlined Structural Validation – Accelerate protein analysis with intuitive tools that merge quantitative metrics (distance tables) and visual trends (histograms) for deeper insights.
Targeted Analysis – Pinpoint critical regions with PySSA’s hotspot display, focusing on key amino acids for detailed structural insights.
Clear Structural Comparison – Visualize alignments with precision, contrasting reference (green) and predicted (element-colored) structures for accurate model validation.
Enhanced Data Interpretation – Streamline structural biology workflows with customizable displays that highlight atomic details and alignment quality.
Three distinct use cases are presented to illustrate the functionality of PySSA. Each use case builds upon the preceding one, and it is therefore recommended to view all three in order to gain a comprehensive understanding of the software's capabilities.